Graphic issue - Screen goes messy

Hello.
Sometimes while I'm playing happen something like this: (Photo of my screen)

My computer still working but can't use the keyboard. The mouse moves but doesn't click.
It only happens whit this game, it has always happened. I have Windows 7 Ultimate x64 and nvidia gtx460m, tried with multiple drivers, maybe is specific for some graphic cards, I tried differents drivers.

So here is it, I didn't find this posted but neither I know which words exactly I should have used to search.

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